CO149 Prevalence of Chain-of-Event and Contributing Conditions Among Treated COVID-19 Patients in the United States: Identifying Risk Factors Associated with Deaths

A 2021 CDC report on 378,048 US deaths attributed to COVID-19 identified a co-occurring diagnosis of chain-of-event condition (COE) (e.g., pneumonia, respiratory failure), or significant contributing (SCC) diabetes, dementia), both; in 91.9% the patients. This study assessed prevalence comorbid COE and/or SCC among diagnosed patients large open-source claims database. Patients with any claim including IQVIA’s longitudinal medical and pharmacy databases from 4/1/2020 4/30/2022 were identified. Among these patients, presence (within +/- 7d diagnosis) history SCC, both, Within this subset, no subsequent activity > 30 days after last flagged. Flagged linked Veritas database containing >33 million death records. 17,682,111 for COVID-19, acute failure (7.4%), pneumonia (5.1%) asphyxia (4.7%) most common conditions. Essential hypertension (36.5%) was followed by hyperlipidemia (22.5%), obesity (19.7%) type 2 diabetes (19.1%). Overall, 970,324 flagged >30 diagnosis; those, 34.6% aged 65-75 42.4% >75 years had flag data. The metabolic is high treated US. Concurrent COE/SCC an end within associated over third elderly findings could be used combination other known risk factors poor outcomes identify at mortality.